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Hippocampal Electrophysiology


Brian Bland's Publications

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  1. Bland BH (1986) Posterior-neodecortication in the rat. Age at operation and experience. Master's Thesis, University of Calgary.
  2. Bland BH (1971) Diencephalic and hippocampal mechanisms of motor activity in the rat. Doctoral Dissertation, University of Western Ontario.

Book Chapters and Reviews

  1. Vanderwolf CH, Bland, BH, Whishaw IQ (1972) Diencephalic, hippocampal, and Neocortical mechanisms in voluntary behavior. In J. Maser (Ed.), Efferent organization and the integration of behavior. New York: Academic Press: 229-262.
  2. Vanderwolf CH, Kramis R, Gillespie LA, Bland BH (1975) Hippocampal rhythmical slow activity and  neocortical low voltage fast activity: Relations to behavior. In K. H. Pribram and R. L. Isaacson (Eds.). The Hippocampus: A comprehensive treatise. New York: Plenum Publishing Corp.: 101-128.
  3. Bland BH (1985) Behavioral correlates and afferent control of hippocampal theta cell discharges. In G. Buzsaki and C.H. Vanderwolf (Eds.), The electrical activity of the archicortex. Pecs: Hungarian Academy of Sciences, 1985, 125-142.
  4. Bland BH (1986) The physiology and pharmacology of hippocampal formation theta rhythms. In J. W. Phillis (Ed.), Progress in Neurobiology, London: Pergamon Press, Ltd. 26: 1-54.
  5. Smythe JW, Colom LV, Bland BH (1992) The extrinsic modulation of hippocampal theta depends on the coactivation of cholinergic and GABA-ergic medial septal inputs. Neuroscience & Biobehavioral Reviews 16: 289-308.
  6. Bland BH, Colom LV(1993) Extrinsic and intrinsic properties underlying oscillation and synchrony in limbic cortex. Progress in Neurobiology, London, Pergamon Press Ltd. 41: 157-208.
  7. Whishaw IQ, Bland BH (1998) Editors, Special Issue: Case Vanderwolf Festschrift Neuroscience and Biobehavioral Reviews 22: 121-370.  
  8. Bland BH, Oddie SD (1998) Anatomical, electrophysiological, and pharmacological studies of the ascending brainstem hippocampal synchronizing pathways. Neuroscience & Biobehavioral Reviews 22: 259-273.
  9. Oddie SD, Bland BH (1998) Hippocampal formation theta activity and movement selection. Neuroscience & Biobehavioral Reviews 22: 221-231.
  10. Whishaw IQ, Bland BH, Cornelius H, Vanderwolf CH (1998) An Introduction. Neuroscience and Biobehavioral Reviews 22: 121-123.
  11. Bland BH (2000) The Medial Septum: Node of the ascending brainstem hippocampal synchronizing pathways. In: The Behavioral Neuroscience of the Septal Region. Robert Numan, Editor, Springer-Verlag-NY, Inc.: 115-145.
  12. Bland BH, Konopacki J (2000) Intracellular recording and staining in the acute in vivo rat using sharp electrodes. Kopf Carrier 52: 1-6.
  13. Konopacki J, Bland BH, Dyck R (2000) Podstawowe techniki mikroelektrofizjologiczne w neurobiologii. Post. High. Med. Dosw 54: 261-278.
  14. Bland BH, Oddie SD (2001) Theta band oscillation and synchrony in the hippocampal formation and associated structures: the case for its role in sensorimotor integration. Behavioral Brain Research 127: 119-136.
  15. Bland BH (2004) The power of theta: providing insights into the role of the hippocampal formation in sensorimotor integration. Hippocampus 14: 537-538.
  16. Bland BH (2007) Anatomical, physiological, and pharmacological properties underlying hippocampal sensorimotor integration. In: Information Processing by Neuronal Populations, Editor(s) Christian Holtscher & Matthias Monk, Cambridge University Press, In Press.

Journal Articles

  1. Bland BH, Cooper RM (1969) Posterior-neodecortication  in the rat. Age at operation  and experience. Journal of Comparative and Physiological Psychology 69: 345-354.
  2. Bland BH, Cooper RM (1970) Experience and vision of the posterior neodecorticate rat. Physiology and Behavior 5: 211-214.
  3. Cooper RM, Bland BH, Gillespie LA, Whitaker RH (1970) Unilateral posterior neocortex and unilateral superior colliculus lesions and visually guided behavior in the rat. Journal of Comparative and Physiological Psychology 72: 286-295.
  4. Bland BH, Vanderwolf CH (1972a) Diencephalic and hippocampal mechanisms of motor activity in the rat.   Effects of posterior hypothalamic stimulation on behavior  and hippocampal slow wave activity. Brain Research 43: 67-88.
  5. Bland BH, Vanderwolf CH (1972b) Electrical stimulation of the hippocampal formation: Behavioral and bioelectrical effects. Brain Research 43: 89-106.
  6. Whishaw IQ, Bland BH, Vanderwolf CH (1972) Hippocampal activity, behavior, self-stimulation, and heart rate during electrical stimulation of the lateral hypothalamus. Journal of Comparative and Physiological Psychology 79: 115-127.
  7. Wishart TB, Bland BH, Vanderwolf CH, Altman JL (1973) Electroencephalographic correlates of behavior  elicited by electrical stimulation of the septum: Seizure induced feeding. Behavioral Biology 9: 763-769.
  8. Andersen P, Bland BH, Dudar JD (1973) Organization of the hippocampal output. Experimental Brain Research 17: 152-168.
  9. Teyler T, Bland BH, Schulte RA (1974) Chronic micro-recording and stimulating system. Physiology and Behavior 12: 503-506.
  10. Bland BH, Kostopoulos G, Phillis JW (1974) Acetylcholine sensitivity of hippocampal formation neurons.  Canadian Journal of Physiology and Pharmacology 52: 966-971.
  11. Bland BH, Andersen P, Ganes T (1975) Two generators of hippocampal theta activity in rabbits. Brain Research 94: 199-218.
  12. Kramis R, Vanderwolf CH, Bland BH (1975) Two types of hippocampal rhythmical slow activity (RSA) in both the rabbit and the rat: Relations to behavior and effects of atropine, diethyl ether, urethane and pentobarbital.   Experimental Neurology 49: 58-85.
  13. Whishaw IQ, Bland BH, Robinson TE, Vanderwolf CH (1976) Neuromuscular blockade: The effects on two hippocampal RSA (theta) systems and neocortical desynchronization. Brain Research Bulletin 1: 573-581.
  14. Bland BH, Whishaw IQ (1976) Generators and topography of hippocampal theta (RSA) in the anaesthetized and freely moving rat. Brain Research 118: 259-280.
  15. Sainsbury RS, Bland BH, Buchan DH (1978) Electrically induced seizure activity in the hippocampus: Time course for post-seizure inhibition of subsequent kindled seizures. Behavioral Biology 22: 479-488.
  16. Whishaw IQ, Bland BH, Bayer SA (1978) Postnatal hippocampal granule cell agenesis in the rat: Effects on two types of rhythmical slow activity (RSA) in two hippocampal generators. Brain Research 146: 249-268.
  17. Bland BH, Sainsbury RS, Creery BL(1979) Anatomical correlates of rhythmical slow wave activity (theta) in the hippocampal formation of the cat. Brain Research 161: 199-209.
  18. Andersen P, Bland BH, Myhrer T, Schwartzkroin PA (1979) Septal hippocampal pathway necessary for dentate theta production. Brain Research 165: 13-22.
  19. Leblanc OM, Bland BH (1979) Developmental aspects of hippocampal electrical activity and motor behavior in the rat. Experimental Neurology 66: 220-237.
  20. Bland BH, Sinclair BR, Jorgenson RG, Keen RA (1980) A direct-drive, non-rotating version of Ranck's microdrive. Physiology and Behavior 24: 395-397.
  21. Creery BL, Bland BH (1980) The ontogeny of fascia dentata electrical activity and motor behavior in the Dutch Belted rabbit (Oryctolagus cuniculus). Experimental Neurology 67: 554-572.
  22. Bland BH, Andersen P, Ganes T, Sveen O (1980) Automated analysis of rhythmicity of physiologically identified hippocampal formation neurons. Experimental Brain Research 38: 205-219.
  23. Sainsbury RS, Bland BH (1981) The effects of selective septal lesions on theta production in CA1 and the dentate gyrus of the hippocampus. Physiology and Behavior 26: 1097-1101.
  24. Bland BH, Sainsbury RS, Seto M, Sinclair BR, Whishaw IQ (1981) The use of sodium pentobarbital for the study of immobility-related (Type 2) hippocampal theta. Physiology and Behavior 27: 363-368.
  25. Sinclair BR, Seto MG, Bland BH (1982) Theta cells in the CA1 and dentate layers of the hippocampal formation: Relations to slow wave activity and motor behavior in the freely moving rabbit. Journal of Neurophysiology 48: 1214-1225.
  26. Bland BH, Seto M, Rowntree CI (1983) The relation of multiple hippocampal theta cell discharge rates to slow wave theta frequency. Physiology and Behavior 31: 111-117.
  27. Bland BH, Seto MG, Sinclair BR, Fraser SM (1984) The pharmacology of hippocampal theta cells: Evidence that the sensory processing correlate is cholinergic. Brain Research 299: 121-131.
  28. Roth SH, Bland BH, MacIver MB (1983) Biphasic actions of pentobarbital on synaptic transmission.  Progress in Neuropsychopharmacology and Biological Psychiatry 7: 821-825.
  29. Rowntree CI, Bland BH (1986) An analysis of cholinoceptive neurons in the hippocampal formation by direct microinfusion.Brain Research 362: 98-113.
  30. MacIver MB, Harris DP, Konopacki J, Roth SH, Bland BH (1986) Carbachol-induced rhythmical slow wave activity recorded from dentate granule neurons in vitro. Proceedings of the Western Pharmacological Society 29: 159-161.
  31. Bland SK, Bland BH (1986) Medial septal modulation of hippocampal theta cell discharges. Brain Research 375: 102-116.
  32. Roth SH, Konopacki J, Bland BH (1987) Pharmacological demonstration of two EEG "theta" generators in hippocampal slices. Proceedings of the Western Pharmacological Society 30: 37-40.
  33. Colom LV, Ford RD, Bland BH (1987) Hippocampal formation neurons code the level of activation of the cholinergic septo-hippocampal pathway. Brain Research 410: 12-20.
  34. Konopacki J, MacIver MB, Bland BH, Roth SH (1987) Theta in hippocampal slices: Relation to synaptic responses of dentate neurons. Brain Research Bulletin 18: 25-27.
  35. Konopacki J, MacIver MB, Roth SH, Bland BH (1987) Carbachol-induced EEG "Theta" activity in hippocampal brain slices. Brain Research 405: 196-198.
  36. Konopacki J, Bland BH, Roth SH (1987) Phase Shifting of CA1 and dentate EEG "theta" in hippocampal formation slices. Brain Research 417: 399-402.
  37. Konopacki J, Bland BH, MacIver MB, Roth SH (1987) Cholinergic theta rhythm in transected hippocampal slices: Independent CA1 and dentate generators. Brain Research 436: 217-222.
  38. Colom LV, Bland BH (1987) State-dependent spike train dynamics of hippocampal formation neurons:  Evidence for theta-on and theta-off cells. Brain Research 422: 277-286.
  39. Konopacki J, Bland BH, Roth SH (1988) Carbachol-induced EEG theta in hippocampal formation slices:  Evidence for a third generator of theta in CA3C area. Brain Research 451: 33-42.
  40. Bland BH, Colom LV (1988) Responses of phasic and tonic hippocampal theta-on cells to cholinergics:  Differential effects of muscarinic and nicotinic activation. Brain Research 440: 167-171.
  41. Konopacki J, Bland BH, Roth SH (1988) Evidence that activation of InVitro hippocampal theta rhythm involves only muscarinic receptors. Brain Research 455: 110-114.
  42. Bland BH, Colom LV, Konopacki J, Roth SH (1988) Intracellular records of carbachol-induced theta rhythm in hippocampal slices. Brain Research 447: 364-368.
  43. Konopacki J, Bland BH, Roth SH (1988) The development of carbachol-induced EEG theta examined in hippocampal formation slices. Developmental Brain Research 38: 229-232.
  44. Colom LV, Christie BR, Bland BH (1988) Cingulate cell discharge patterns related to hippocampal EEG and their modulation by muscarinic and nicotinic agents. Brain Research 460: 329-338.
  45. Code WE, Roth SH, Bland BH, Strunin L (1988) The effects of halothane on hippocampal theta rhythm in the freely moving rat. Canadian Journal of Anaesthesia 35: 5100-5101.
  46. Ford RD, Colom LV, Bland, BH (1989) The classification of medial septum-diagonal band cells as theta-on or theta-off in relation to hippocampal EEG states. Brain Research 493: 269-282.
  47. Bland BH, Colom LV (1989) Preliminary observations on the physiology and pharmacology of hippocampal theta-off cells, Brain Research 505: 333-336.
  48. Bland BH, Colom LV, Ford RD (1990) Responses of septal theta-on and theta-off cells to activation of the dorsomedial-posterior hypothalamic region, Brain Research Bulletin 24: 71-79.
  49. Bland BH, Colom LV, Mani TE (1990) An improved version of a direct-drive, non-rotating manual microdrive.  Brain Research Bulletin 25: 441-443.
  50. Colom LV, Bland BH (1991) Medial septal cell interactions in relation to hippocampal field activity and the effects of atropine. Hippocampus 1: 15-30.
  51. Smythe JW, Christie BR, Colom LV, Lawson VH, Bland BH (1991) Hippocampal theta field activity and Theta-on/Theta-off cell discharges are controlled by an ascending hypothalamo-septal pathway.  J. Neuroscience 11: 2241-2248.
  52. Colom LV, Nassif-Caudarella S, Dickson CT, Smythe JW, Bland BH (1991) In vivo intrahippocampal microinfusion of carbachol and bicuculline induces theta-like oscillations in the septally deafferented hippocampus.  Hippocampus 4: 381-390.
  53. Konopacki J, Bland BH, Colom LV, Oddie SD (1992) In vivo intracellular correlates of hippocampal formation theta-on and theta-off cells. Brain Research 586: 247-255.
  54. Lawson VH, Bland BH (1993) The role of the septohippocampal pathway in the regulation of hippocampal field activity and behavior. Analysis by the intraseptal microinfusion of carbachol, atropine, and procaine.  Experimental Neurology 120: 132-144.
  55. Edgington ES, Bland BH (1993) Randomization tests: Application to single-cell and other single-unit neuroscience  experiments. Journal of Neuroscience Methods 47: 169-177.
  56. Vertes RP, Colom LV, Fortin WJ, Bland BH (1993) Brainstem sites for the carbachol  elicitation of the hippocampal theta rhythm in the rat. Experimental Brain Research 96: 419-429.
  57. Dickson CT, Trepel C, Bland BH (1994) The extrinsic modulation of theta field activity in the entorhinal cortex of the anesthetized rat. Hippocampus 4: 37-52.
  58. Oddie SD, Bland BH, Colom LV, Vertes RP (1994) The midline posterior hypothalamic region comprises a critical part of the ascending brainstem hippocampal synchronizing pathway. Hippocampus 4: 454-473.
  59. Bland BH, Oddie SD, Colom LV, Vertes RP (1994) The extrinsic modulation of medial septal cell discharges by the ascending brainstem hippocampal synchronizing pathway. Hippocampus 4: 649-660.
  60. Vertes RP, Crane AM, Colom LV, Bland BH (1995)Ascending projections of the posterior nucleus of the hypothalamus in the rat: PHA-L analysis in the rat. Journal of Comparative Neurology 359: 90-116.
  61. Bland BH, Konopacki J, Kirk IJ, Oddie SD, Dickson CT (1995) Discharge patterns of hippocampal theta-related cells in the caudal diencephalon of the urethane-anesthetized rat. Journal of Neurophysiology 74: 322-333.
  62. Dickson CT, Kirk IJ, Oddie SD, Bland BH (1995) The classification of theta-related cells in the entorhinal cortex: Cell discharges are controlled by the ascending brainstem synchronizing pathway in parallel with hippocampal theta-related cells.  Hippocampus 5: 306-319.
  63. MacIver MB, Mandema JW, Stanski DR, Bland BH (1996) Thiopental uncouples hippocampal and cortical synchronized EEG activity. Anesthesiology 84: 1411-1424.
  64. Bland BH, Trepel C, Oddie SD, Kirk IJ (1996) Intraseptal microinfusion of muscimol: Effects on hippocampal formation theta field activity and phasic theta-ON cell discharges. Experimental Neurology 138: 286-297.
  65. Oddie SD, Stefanek W, Kirk IJ, Bland BH (1996) Intraseptal procaine abolishes hypothalamic stimulation induced wheel running and hippocampal theta field activity in rats. Journal of Neuroscience 16: 1948-1956.
  66. Kirk IJ, Konopacki J, Oddie SD, Bland BH (1996) Evidence for differential control of posterior hypothalamic, supramammillary, and medial mammillary theta-related cellular discharge by ascending and descending pathways. Journal of Neuroscience 16: 5547-5554.
  67. Oddie SD, Kirk IJ, Whishaw IQ, Bland BH (1997) The hippocampal formation is involved in movement selection: Evidence from medial septal cholinergic modulation and concurrent slow-wave (theta rhythm) recording. Behavioral Brain Research 88: 169-180.
  68. Hanada Y, Hallworth NE, Szgatti TL, Bland BH (1999) The distribution and analysis of hippocampal theta-related cells in the pontine region of the urethane-anesthetized rat. Hippocampus 9: 288-302.
  69. Bland BH, Oddie SD, Colom LV (1999) Mechanisms of neural synchrony in the septohippocampal pathway underlying hippocampal theta  generation. Journal of Neuroscience 19: 3223-3237.
  70. Natsume K, Hallworth NE, Szgatti TL, Bland BH (1999) Hippocampal theta-related cellular activity in the superior colliculus of the urethane-anesthetized rat. Hippocampus 5: 500-509.
  71. Natsume K, Hallworth NE, Szgatti TL, Bland BH (1998) Theta-related cells in the superior colliculus of the urethane-anesthetized rat. Neuroscience Res. 22: 462, Suppl. S222.
  72. Oddie SD, Kirk IJ, Gorny BP, Whishaw IQ, Bland BH (2002) Impaired dodging in food-conflict following  fimbria-fornix transection in rats: A novel hippocampal formation deficit. Brain Research Bulletin 57: 565-573.
  73. Bland BH, Konopacki J, Dyck R (2002) Relationship between membrane potential oscillations and rhythmic discharges in identified hippocampal theta-related cells. Journal of Neurophysiology 88: 3046-3066.
  74. Bland BH, Bland CE, Colom LV, Roth SH, DeClerk S, Dypvik A, Bird J, Deliyannides A (2003) Effect of halothane on type 2 immoblity-related theta field activity and theta-ON/theta-OFF cell discharges. Hippocampus 13: 38-47.
  75. Scarlett DA, Dypvik AT, Bland BH (2004) A comparison of spontaneous and septally-driven hippocampal theta field and theta-related cellular activity. Hippocampus14: 99-106.
  76. Konopacki J, Bland BH, Dyck R (2003) Intracellular recording and labeling of neurons in midline structures of the rat brain in vivo using sharp electrodes. Journal of Neuroscience Methods 127(1): 85-93.
  77. Dypvik AT, Bland BH (2004) Functional connectivity between the red nucleus and the hippocampus supports the role of the hippocampal formation in sensorimotor integration. Journal of Neurophysiology.
  78. Hallworth NE, Bland BH (2004) Basal ganglia--hippocampal interactions support the role of the hippocampal formation in sensorimotor integration. Experimental Neurology 188(2):430-43.
  79. Bland BH (2004) The power of theta: providing insights into the role of the hippocampal formation in sensorimotor integration. Hippocampus14(5): 537-8. Review. No abstract available.
  80. Bland BH, Konopacki J, Dyck R (2005) Heterogeneity among hippocampal pyramidal neurons revealed by their relation to theta-band oscillation and synchrony. Experimental Neurology195(2):458-74.
  81. Jackson J, Bland BH (2006) Medial septal modulation of the ascending brainstem hippocampal synchronizing pathways in the anesthetized rat. Hippocampus 16(1): 1-10.
  82. Bland BH, Bird J, Jackson J, Natsume K (2006) Medial septal modulation of the ascending brainstem hippocampal synchronizing pathways in the freely moving rat. Hippocampus 16: 11-19.
  83. Bland BH, Jackson J, Derie-Gillespie D, Azad T, Rickhi A, Abriam J (2006) Amplitude, frequency, and phase analysis of hippocampal theta during sensorimotor
    processing in a jump avoidance task. Hippocampus 16: 673-681.
  84. Bland BH, DeClerck S, Jackson J, Glasgow S, Oddie SD (2007) Septohippocampal properties of N-Methyl-D-Aspartate–induced theta-band oscillation and synchrony.
    Synapse 61: 185-197.
  85. Bland BH, Mestek P, Jackson J, Crooks R, Cormican A. To move or not: previous experience in a runway avoidance task determines the appearance of hippocampal
    Type 2 sensory processing theta. Behavioral Brain Research, Published February 7, 2007. S0166-4328(07)00080-0 DOI: doi:10.1016/j.bbr.2007.02.002
  86. Crooks R, Jackson J, Bland BH (In Prep) Evidence that the hippocampal desynchronizing effects of electrical stimulation of the median raphe are mediated by the medial septum.
  87. Jackson J, Cormican A, Bland BH (In Prep) Mechanisms and significance of median raphe-induced
    hippocampal desynchronization.