Dynamic Development


Main Page Dynamic Development

The Foundations of Developmental Biology


From Sperm and Egg to Embryo

Genetic Regulation of Development

Organizing the Multicellular Embryo

Generating Cell Diversity

Dynamic Development at a Glance

Learning Resources

Research Resources

The Developmental Biology Journal Club

Developmental Biology Tutorial

Oocyte Maturation

How does an oocyte become an egg?

Learning Objectives

  • Review hormonal interactions in mammals and frogs.
  • What is unusual about the mechanism of action of progesterone in promoting oocyte maturation?
  • How did Yoshio Masui demonstrate the presence of maturation promotion factor and cytostatic factor?
  • What is MPF, and how was its identity determined?
  • What is CSF, and how was its identity determined?
  • Review the interactions among p34, cyclin and c-MOS
  • What effect does alpha- amanitin have on progesterone-induced amphibian oocyte maturation? Why?

Digging Deeper:

Recent Literature

de Vantéry, C., Stutz, A., Vassalli, J.D. and Schorderet-Slatkine, S. 1997. Acquisition of meiotic competence in growing mouse oocytes is controlled at both translational and posttranslational levels. Develop. Biol. 187: 43-54.

Kume, S., Yamamoto, A., Inoue, T., Muto, A., Okano, H. and Mikoshiba, K. 1997. Developmental expression of the inositol 1,4,5-triphosphate receptor and structural changes in the endoplasmic reticulum during oogenesis and meiotic maturation of Xenopus laevis. Develop. Biol. 182: 228-239.

Thibier, C., De Smedt, V., Poulhe, R., Huchon, D., Jessus, C. and Ozon, R. 1997. In vivo regulation of cytostatic activity in Xenopus metaphase II-arrested oocytes. Develop. Biol. 185: 55-66.

Related Topic

Regulation of Protein Synthesis during Oogenesis, Oocyte Maturation and Early Development


Browder, L.W., Erickson, C.A. and Jeffery, W.R. 1991. Developmental Biology. Third edition. Saunders College Pub. Philadelphia.

Dynamic Development at a Glance
Main Page Dynamic Development

Dynamic Development is a Virtual Embryo learning resource

This material may be reproduced for educational purposes only provided credit is given to the original source.
Leon Browder & Laurie Iten (Ed.) Dynamic Development
Last revised Wednesday, June 17, 1998