THE UNIVERSITY OF CALGARY
FACULTY OF SCIENCE
MIDTERM EXAMINATION II
March 15, 1991
TIME: 50 minutes
TOTAL POINTS: 100
(25 ) 1. Describe Rappaport's experiments demonstrating the relationship between formation of the cleavage furrow and the asters.
(20) 2. Discuss the evidence indicating that at least some cytoplasmic determinants are stored mRNA.
(25 ) 3. Discuss the nuclear transplantation experiments on Rana by Briggs and King. Address the following points:
What were the objectives?
Describe their techniques
What results were obtained?
What conclusion(s) did they draw?
(15 ) 4. What are the effects of laminin and fibronectin on neural crest cell migration? Cite experimental evidence to support your answer.
(15 ) 5. The discovery of XTC-MIF represents a milestone in our understanding of cell determination during development. What is this substance, how was it discovered, and what do we know about its homologue in the embryo?