February 7, 1994 TIME: 50 minutes



(20) 1. When is the ZP-3 gene expressed, and how is its expression regulated? Cite experimental evidence to support your statements.

(20) 2. Describe the origin of the acrosome during mammalian spermiogenesis (5 points) and the composition, structure, and function of the mammalian acrosome (5 points). Compare the sea urchin and mammalian acrosomes (5 points) and describe how the acrosome reaction is regulated in sea urchins (5 points). Cite experimental evidence where relevant.

3. Define or describe

(4) a. fertilization potential.

(8) b. c-mos.

(8) c. TFIIIA.