Dr. Leon W. Browder


B.A. University of Colorado, 1962

M.S. Louisiana State University, 1964

Ph.D. Zoology, University of Minnesota, 1967

Professor, Department of Biological Sciences
University of Calgary,
Calgary, Alberta, Canada T2N 1N4

Phone: (403) 220-6787

email: browder@acs.ucalgary.ca

RESEARCH INTERESTS


My research is focused on the study of embryonic development of Xenopus laevis, the South African Clawed Frog. This organism has long served as a paradigm for vertebrate development and has played a major role in most of the significant discoveries in developmental biology for the last two decades.

Current research involves the use of the technique of transgenesis to study the roles of pagliaccio and ING1 in development.

SELECTED PUBLICATIONS


Gibson, A.W., Ye, R., Johnston, R.N. and Browder, L.W. 1992. A possible role for c-MYC oncoproteins in posttranscriptional regulation of ribosomal RNA. Oncogene 7: 2363-2367.

Browder, L.W., Wilkes, J. and Rodenhiser, D.I. 1992. Preparative labelling of proteins with [35S] methionine. Analyt. Biochem. 204:
85-89.

Gibson, A.W., Ye, R., Johnston, R.N. and Browder, L.W. 1992. Multiple antigens recognized by anti-c-myc antibodies in human cells and Xenopus oocytes. Biochem. Cell Biol. 70: 998 - 1005.

Marsden, M., Nickells, R.W., Kapoor, M. and Browder, L.W. 1993. The induction of pyruvate kinase synthesis by heat shock in Xenopus laevis embryos. Develop. Genetics 14: 51-57.

Fraser, S.D., Wilkes-Johnston, J. and Browder, L.W. 1996. Effects of c-myc first exons and 5' synthetic hairpins on RNA translation in oocytes and early embryos of Xenopus laevis. Oncogene12: 1223-1230.

Browder, L.W. 1997. Gene expression, cell determination and differentiation. In Textbook of Tissue Engineering, edited by R. Lanza, R. Langer, and W. Chick. R.G. Landes, Austin, Texas. Pages 79-86.

Strugnell, T.D. and Browder, L.W. 1997. Effects of cyclin A2 noncoding regions on reporter gene translation during early development of Xenopus laevis. Developmental Genetics 21: 134-145.

Fraser, S.D. and Browder, L.W. 1997. Stimulation of translation and cytoplasmic polyadenylation by the Xenopus c-mycI 3-untranslated region. Differentiation 62: 51-62.

Browder, L.W., Wilkes-Johnston, J. and Fraser, S.D. 1997. 5'-3' interactions in regulation of translation in Xenopus early embryos. Biochemistry and Cell Biology. In Press.

Browder, L.W., C. A. Erickson and W.R. Jeffery. 1991. Developmental Biology. Third Edition. Saunders College Publishing. Philadelphia.




Revised January 19, 1998 Copyright © 1996, 1997, 1998 Leon W. Browder