Publications

(Researchers from Derksen group are underlined, corresponding author(s) denoted by *)

17) LeGay, C. M.;Derksen, D. J.* Structure-Activity Relationship (SAR) Studies of Transient Receptor Potential (TRP) Channel Modulators. In 2017 Medicinal Chemistry Reviews; Bronson, J. J., Ed.; Medicinal Chemistry Division of the American Chemical Society: Washington, DC, 2017; Vol. 52; pp. 443-463. 

Link: Medicinal Chemistry Reviews


16) Papatzimas, J. W.; Gorobets, E.; Brownsey, D. K.; Maity, R.; Bahlis, N. J.; Derksen, D. J.* A General Strategy for the Preparation of Thalidomide-Conjugate Linkers SynLett 2017, 28, 2881-2885.  Invited manuscript for special issue dedicated to Professor Victor Snieckus.

doi: 10.1055/s-0036-1588539


15) Gorobets, E.; Wong, N. E.; Paton, R. S.; Derksen, D. J.* Divergent Photocyclization/1,4-Sigmatropic Rearrangements for the Synthesis of Sesquiterpenoid Derivatives Org. Lett. 2017, 19, 484-487.

doi: 10.1021/acs.orglett.6b03635


14) Lee, J.; Papatzimas, J. W.; Bromby, A. D.; Gorobets, E.; Derksen, D. J.*  Thiaporphyrin-mediated Photocatalysis Using Red Light RSC Adv. 2016, 6, 59269-59272.

doi: 10.1039/c6ra11374e


13) LeGay, C. M.; Gorobets, E.; Iftinca, M.; Ramachandran, R.; Altier, C.; Derksen, D. J.* Natural-Product-Derived Transient Receptor Potential Melastatin 8 (TRPM8) Channel Modulators Org. Lett. 2016, 18, 2746-2749.

doi: 10.1021/acs.orglett.6b01222


12) Gorobets, E.; Parvez, M.; Derksen, D. J.; Keay, B. A.* Generation of Benzyne Species from Diphenylphosphoryl Derivatives - Simultaneous Exchange of Three Functional Groups Chem. Eur. J. 2016, 22, 8479-8482.

doi: 10.1002/chem.201601370


11) Kerr, R. G.*; Brophy, S.; Derksen, D. J.* Synthesis and Evaluation of Anti-inflammatory Activity of Derivatives of the Marine Natural Products Fuscol and Eunicol Bioorg. Med. Chem. Lett. 2014, 24, 4804-4806.

doi: 10.1016/j.bmcl.2014.09.008


10) Harty, M.; Nagar, M.; Atkinson, L.; LeGay, C. M.; Derksen, D. J.* Bearne, S. L.* Inhibition of Serine and Proline Racemases by Substrate-Product Analogues Bioorg. Med. Chem. Lett. 2014, 24, 390-393.

doi: 10.1016/j.bmcl.2013.10.061

 

9) Pustam, A.; Smith, C.; Deering, C.; Grosicki, K.; Leng, T.-Y.; Yang, J.; Lin, S.; Pink, D.; Gill, T.; Graham, L.; Derksen, D.; Bishop, C.; Demont, M.; Wyeth, R.; Smith-Palmer, T.* Interactions of Protamine with the Marine Bacterium, Pseudoalteromonas sp. NCIMB 2021. Lett. Appl. Microbiol. 2013, 58, 225-230.

doi: 10.1111/lam.12177


8) LeGay, C. M.; Boudreau, C. G.; Derksen, D. J.* Elucidating Absolute Configuration of Unsaturated Alcohols via Enantioselective Acylation Reactions. Org. Biomol. Chem. 2013, 11, 3432-3435.

doi: 10.1039/C3OB40709H 


7) Huang, Z.; Derksen, D. J.; Vederas, J. C. Preparation and Use of Cysteine Orthoesters for Solid-Supported Synthesis of Peptides. Org. Lett. 2010, 12, 2282-2285.

doi: 10.1021/ol100645t 


6) Derksen, D. J.; Boudreau, M. A.; Vederas, J. C. The Role of Hydrophobic Interactions in the N-terminus of Leucocin A and Pediocin PA-1. Chembiochem, 2008, 9, 1898-1901.

doi: 10.1002/cbic.200800272


5) van Belkum, M. J.; Derksen, D. J.; Franz, C. M. A. P.; Vederas, J. C. Structure Function Relationship of Inducer Peptide Pheromones Involved in Bacteriocin Production in Carnobacterium maltaromaticum and Enterococcus faecium. Microbiology, 2007, 153, 3660-3666.

doi: 10.1099/mic.0.2007/009183-0


4) Pattabiraman, V. R.; Stymiest, J. L.; Derksen, D. J.; Martin, N. I.; Vederas, J. C. Multiple On-Resin Olefin Metathesis to Form Ring Expanded Analogues of the Lantibiotic Peptide, Lacticin 3147 A2. Org. Lett. 2007, 9, 699-702. 

doi: 10.1021/ol063133j  


3) Derksen, D. J.; Stymiest, J. L.; Vederas, J. C. Antimicrobial Leucocin Analogues with a Disulfide Bridge Replaced by a Carbocycle or by Noncovalent Interactions of Allyl Glycine Residues. J. Am. Chem. Soc. 2006, 128, 14252-14253.

doi: 10.1021/ja066203q


2) Gursky, L. J.; Martin, N. I.; Derksen, D. J.; van Belkum, M. J.; Kaur, K.; Vederas, J. C.; Stiles, M. E.; McMullen, L. M. Production of Piscicolin 126 by Carnobacterium maltaromaticum UAL26 is Controlled by Temperature and Induction Peptide Concentration. Arch. Microbiol. 2006, 186, 317-325.

doi: 10.1007/s00203-006-0147-z


1) Spantulescu, M. D.; Jain, R. P.; Derksen, D. J.; Vederas, J. C. Photolysis of Diacyl Peroxides: A Radical Based Approach for the Synthesis of Functionalized Amino Acids. Org. Lett. 2003, 5, 2963-2965. 

doi: 10.1021/ol035125y

© Darren Derksen 2017