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WELCOME TO THE PERINATAL RESEARCH LABORATORIES OF
DR. FRANCINE G. SMITH


The major thrust of our research is to explore the physiology of the newborn kidney and the neurohumoral factors that modulate kidney function during the critical adaptation to life after birth. In addition, we are investigating putative mechanisms that may regulate body fluid homeostasis during the perinatal period and throughout maturation.

Experiments are designed to allow us to integrate many different aspects of the physiological changes taking place during development. In conscious young animals, we study a variety of physiological variables including parameters of cardiovascular function (e.g. arterial baroreflex), renal function (e.g. glomerular filtration rate, clearances, reabsorptions) and endocrine function (e.g. plasma renin activity, arginine vasopressin), as well as responses to perturbations in vascular volume or blood pressure (e.g. haemorrhage, furosemide).

More information about the areas of study and current experiments we are currently pursuing can be found at “on-going research.”