Adjusted Survival Analysis Programs


The following abstract was published in the journal Medical Decision Making (1998;18:490) and compares two statistical methods for calculating and plotting adjusted survival curves from Cox Proportional Hazards Models.


PLOTTING ADJUSTED SURVIVAL CURVES FROM PROPORTIONAL HAZARDS MODELS: A COMPARISON OF TWO METHODS.


WA Ghali, H Quan, R Brant, CM Norris, G van Melle, ML Knudtson, for the APPROACH (Alberta Provincial Program for Outcome Assessment in Coronary Heart Disease) Investigators.

University of Calgary, Calgary, AB, Canada

APPROACH is a large inception cohort study which captures all patients undergoing cardiac catheterization in Alberta, Canada. We used data on 11,804 patients from this study to examine the two year survival experience of diabetics vs. non-diabetics, while controlling for covariates such as left ventricular ejection fraction, coronary anatomy, sociodemographic variables, and comorbidities. Here, we present a comparison of two methods for calculating covariate-adjusted survival curves.

The most commonly-used method for generating such curves is the "average covariate method", in which the average values of covariates of interest are entered into a proportional hazards regression equation to generate adjusted survival estimates. We used data from the APPROACH study to compare the survival curves generated by the "average covariate method" with those generated by a newer method - the "corrected group prognosis method" - in which a survival curve for each level of covariates is calculated, after which an average survival curve is calculated as a weighted average of the individual survival curves. The resulting adjusted survival curves are shown below, along with the corresponding unadjusted survival curves for diabetics and non-diabetics.

two curves

For these data, the commonly-used "average covariate method" yields misleading adjusted survival curves which do not fall between the unadjusted curves for diabetics and non-diabetics. Investigators should be cautious when using the "average covariate method", and should consider the "corrected group prognosis method" if resulting adjusted survival curves fail to fall between the unadjusted curves.

Below are four computer files which can be saved to your PC to experiment with the use of these two statistical methods:

If using SAS Version 7 or higher please download the additional file before running the survival program.

Data set SAS program

"sample.sas" - a SAS program which creates a SAS data file for use as an example dataset to which the following SAS programs can be applied. The dataset contains 5,000 observations.

Survival SAS program

1. "mean.sas" - a SAS program which calculates and plots unadjusted and adjusted survival curves. The adjusted curves are calculated using the Mean of Covariates Method.

2. "weight.sas" - a SAS program which calculates and plots unadjusted and adjusted survival curves. The adjusted curves are calculated using the Corrected Group Prognosis Method.

The programs and sample dataset should be easy to use for individuals who are familiar with SAS programming. The programs can easily be modified for use with other datasets. We have provided comment statements with the SAS programs which should facilitate the modification of the programs for use with other data.

For STATA versions of the above programs:

For S-plus versions of the above programs, please click here: R Brant .

If you have questions or comments regarding this website, please e-mail WA Ghali or H Quan .