The research in our laboratory is divided into two separate components:

  1. 1.A basic research program that focuses on the gene regulatory network controlling proximal limb development in mice, with a special emphasis on the function and regulation of the Shox2 gene. We are also studying the function of Shox2 in the development of the hindbrain.

  2. 2.A clinically relevant research program that seeks to understand the cis-regulation of the human SHOX gene. This study is aimed at understanding how disruptions of noncoding sequences near SHOX cause limb deformities in humans.

For details on each of these aspects of our research, click on the thumbnails below to access four of our representative publications.


   Our research has been funded by these agencies: