Dr. Kenneth K.-S. Ng



Associate Professor
Department of Biological Sciences
University of Calgary
2500 University Drive, N.W.
Calgary, Alberta, Canada
T2N 1N4

Phone: (403) 220-4320
Fax: (403) 289-9311
E-mail: ngk@ucalgary.ca

Welcome!


  • Publications indexed by Pubmed
  • Google Scholar

  • Our primary research interest is in understanding how biological macromolecules function at the molecular level.

    Our lab is particularly interested in understanding how the three-dimensional structures of proteins have evolved to act as highly specific and efficient chemical catalysts (enzymes) or binding proteins.

    The main techniques that we use for our studies are molecular biology, protein expression and purification, and X-ray crystallography. We also use other biochemical, biophysical and computational techniques to explore how enzymes and binding proteins function.


    Research Interests

    Our lab focuses on two different systems:

  • RNA-dependent RNA Polymerases
    • RNA-dependent RNA polymerases are the central enzymes responsible for replicating the genomes of positive-strand RNA viruses. Positive-strand RNA viruses are the cause of many human diseases -- such as polio, the common cold, hepatitis A, hepatitis C, dengue fever, viral encephalitis (West Nile virus), viral gastroenteritis (Norwalk virus) and Severe Acute Respiratory Syndrome (SARS). Positive-strand RNA viruses also cause many serious diseases in other animals (for example, foot-and-mouth disease, rabbit hemorrhagic disease, feline calicivirus disease, porcine respiratory and reproductive syndrome, and equine viral arteritis) and plants (for example, plum pox and barley yellow disease).

    • Caliciviruses
  • Carbohydrate-binding proteins


  • Local access to references and journals

  • University of Calgary Library
  • UofC Ebooks
  • UofC SpringerLink Books
  • UofC Ebrary
  • UofC Health Sciences Ebooks
  • Dictionaries and Encyclopedias

  • Oxford English Dictionary Online
  • Oxford Reference Online
  • Encyclopedia of Life Sciences
  • Journal Indexes

  • Faculty of 1000
  • Web of Knowledge
  • Web of Science
  • SpringerLink
  • ScienceDirect
  • Wiley Journals
  • Scopus
  • General

  • Cell
  • Nature
  • PNAS
  • Science
  • Structure and Crystallography

  • Acta Crystallographica Sect. D
  • Structure
  • Space Group Diagrams -- Dept. Chem., Birkbeck College, UCL
  • Chemistry

  • Royal Society of Chemistry
  • Biochemistry

  • Analytical Biochemistry
  • Archives of Biochemistry and Biophysics
  • Biochemical and Biophysical Research Communications
  • Biochemistry (ACS)
  • Biochemistry and Molecular Biology Education
  • Journal of Biological Chemistry
  • Journal of Molecular Biology
  • Methods in Enzymology
  • Annual Reviews of Biochemistry
  • Virology

  • Journal of General Virology
  • Journal of Virology
  • Virology

  • Research links

  • AGC -- Alberta Glycomics Centre
  • CFG -- Consortium for Functional Glycomics
  • Glyco3D -- CERMAV - CNRS, Grenoble
  • GlycoSciences.DE -- SWEET2 and other useful tools and databases from Germany
  • Linker Database -- Centre for Integrative Bioinformatics from Vrije Universiteit, Amsterdam
  • Catalytic Site Atlas -- Janet Thornton, EBI
  • Enzyme Structure Database -- Janet Thornton, EBI, PDBSum

  • Local links

  • University of Calgary
  • Department of Biological Sciences
  • Departmental Home Page for Dr. Ng
  • Protein Crystallography Facility at the University of Calgary

  • Teaching links

  • Info for Biochemistry Majors -- at the University of Calgary
  • Biochemistry Teaching (Dr. Isabelle Barrette-Ng) -- Some very interesting interactive tutorials & quizzes
  • University of Rochester -- Crystallography & Enzymology -- ( Dr. Joseph E. Wedekind) -- Some very nice content
  • BCEM 543 -- Enzymology
  • BCEM 731 -- Protein & Metabolic Engineering
  • MDSC 755.08 -- Biochemistry and Molecular Biology

  • Useful Sites

  • NIST Time Server -- Mountain time zone

  • This page was last updated on December 10, 2014. Thanks for visiting!