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Kusala M. Jayasuriya  MSc Student
Honours BSc University of Toronto
MSc Dissertation: Determination of first spike latency in DCN cells
July 2009.

Current Gig:
MBA Program
University of Alberta
Edmonton Alberta Canada

kmjayasu@ucalgary.ca
Training
2007
Honours BSc Molecular Genetics
Physiology / Neuroscience
University of Toronto
Toronto ON Canada
2007 - 2009
 MSc - Neuroscience
University of Calgary
Supervisor: R.W. Turner


Awards
2004 - 2005
- Top Poster Presentation
Hospital Sick Children, Toronto
- Summer Research Scholarship (2)
S. Lunenfeld Res. Inst., Toronto
- SPR Student Research Award
N. American Soc. Pediatric. Res.
2006 - 2007
 - Gordon Cressy Leadership Award
University of Toronto
- Provost Delworth Grad. Schol.
University of Toronto
- National Neuroscience Competition
University of Calgary


MSc
- Graduate Research Scholarship
- AHFMR Studentship
- Univ. Calgary Open Scholarship
- AHFMR MBA Studentship


Research Focus: Role of IH in regulating deep cerebellar nuclear output
Approach: Electrophysiology in vitro, pharmacology, immunocytochemistry, microscopy
Preparations: In vitro slice preparations, tissue sections
Below are short summaries of projects published from my research.
BSc Thesis research: I worked on projects in several labs at the University of Toronto that ranged from stem cell technology to electrophysiology. I completed two BSc honours theses dealing with genetic screening for early detection of bone cancer and the expression profiles of a chloride transporter in the zebrafish visual system.
Western blot analysis of tissue factor release Effect of volutrauma on the extrinsic coagulation cascade
    Here we showed that the high tidal volume activates the extrinsic coagulation cascade in the newborn rat but not in the adult. Exposure to volutrauma for as short as 15 min significantly increased the clot time in newborns. We speculate that activation of the coagulation cascade is mediated by Tissue Factor (TF) release. This study brings valuable clinical insights into the use of mechanical ventilation in premature babies. PDF
MSc Thesis research: My current work deals with the properties and functional role of IH channels in DCN cells.
Biocytin-filled DCN neuron and MAP-2 labeled dendritic processes Model - Deep nuclear neurons
    Deep nuclear neurons represent the final output of cerebellum after integrating afferent excitatory pontine inputs and inhibitory input from cerebellar cortical Purkinje cells. These cells spontaneously discharge at rest but can respond to Purkinje cell inhibition with a transient rebound burst discharge. My project involves the use of patch clamp recordings and stimulation of synaptic inputs to understand the regulation and functional role of burst output in response to physiological patterns of input.

Peer-reviewed Publications

Chan, A., Jayasuriya, K., Berry, L., Roth-Kleiner, M., Post, M. and Belik, J. (2006) Volutrauma activates the clotting cascade in the newborn but not adult rat. Am. J. Physiol. Lung Cell Mol. Physiol. 290: L754-L760.


Invited Reviews and Book Chapters:

Tadayonnejad, R., Anderson, D., Molineux, M.L., Mehaffey, W.H., Jayasuriya, K. and Turner, R.W. Rebound discharge in deep cerebellar nuclear neurons in vitro. Cerebellum 9(3): 352-374. PDF

Abstracts - Published work

Chan, A., Jayasuriya, K., Parmar, N., Berry, L. and Belik, J. (2007) Covalent antithrombin-heparin complex neutralizes procoagulant activity induced by ventilation in the newborn rat. XXI Cong Int. Soc. Thrombosis and Haemostasis, Geneva, Switzerland.

Chan, A., Jayasuriya, K., Berry, L., Roth-Kleiner, M., Post, M. and Belik, J. (2006) Volutrauma activates the clotting cascade in the newborn but not adult rat. Ped. Acad. Soc., Washington DC.

Jayasuriya, K. and Woodin, M. (2006) Developmental regulation of GABA and KCC2 in Zebrafish (Danio rerio) visual system.
- Ontario Biology Day, London ON.
- Int. Developmental Perinatal Workshop, Toronto ON.
- Visual system Zoology Res. Symp., University of Toronto, ON.

Jayasuriya, K. and Belik, J. (2006) N20 exposure and NOS expression and activity. Samuel Lunenfeld Res. Symp., Toronto ON.

Jayasuriya, K. and Belik, J. (2004) Volutrauma activates the clotting cascade in the newborn rat.
- Ann. Respiralogy Day, Toronto ON.
- Int. Develop. Perinatal Biology Workshop, Toronto ON.
- Samuel Lunenfeld Res. Symp., Toronto ON.

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