Lab Publications – Since 2000

I. Peer-reviewed Publications

Lemon, N. and Turner, R.W. (2000) Conditional backpropagation generates burst discharge in a sensory neuron. J. Neurophysiology 89: 1519-1530. PDF

Rashid, A.J., Morales, E., Turner, R.W ., and Dunn, R.J. (2001) The contribution of dendritic Kv3 K+ channels to burst discharge in a sensory neuron. J. Neuroscience 21(1): 125-135. PDF

Doiron, B., Longtin, A., Turner, R.W. and Maler, L. (2001) Model of conditional backpropagation in a sensory neuron. J. Neurophysiology 86: 1523-1545. PDF

Rashid, A.J., Dunn, R.J., and Turner, R.W. (2001) A prominent soma-dendritic distribution of Kv3.3 K+ channels in electrosensory and cerebellar neurons. J. Comparative Neurology 441(3): 234-247. PDF

Doiron, B., Noonan, L., Lemon, N., and Turner, R.W. (2003) Persistent Na+ current modifies burst discharge by regulating conditional backpropagation of dendritic spikes. J. Neurophysiology 89(1): 324-337. PDF

Noonan, L., Doiron, B., Laing, C.R., Longtin, A. and Turner, R.W. (2003) A dynamic dendritic refractory period regulates burst discharge in the electrosensory lobe of weakly electric fish. J. Neuroscience 23(4): 1524-1534. PDF

Laing, C.R., Noonan, L., Turner, R.W. and Maler, L. (2003) Burst Excitability. J Computational Neuroscience 14(3): 329-242. PDF

Fernandez F.R, Morales, E., Rashid, A.J., Dunn, R.J. and Turner, R.W. (2003) Inactivation of Kv3.3 K+ channels in heterologous expression systems. J. Biological Chemistry 278(42): 40890-40898. PDF

McKay,B.E., Molineux, M.L. and Turner, R.W. (2004) Biotin is endogenously expressed in select regions of the rat central nervous system . J. Comparative Neurology 473: 86-96. PDF

Morales, E.*, Fernandez F.R.*, Sinclair, S., Molineux, M.L, Mehaffey, H.W. and Turner, R.W. (2004) Releasing the peri-neuronal net to patch clamp neurons in the adult CNS. Pflugers Archiv 448(2): 248-58. PDF *Shared first author.

McKay, B.E. and Turner, R.W. (2004) Kv3 K+ channels enable burst output in rat cerebellar Purkinje cells. European J. Neuroscience 20(3): 729-739. PDF

Fernandez, F.R.*, Mehaffey, W.H.*, Molineux, M.L. and Turner, R.W. (2005) High threshold K+ current increases gain by offsetting a frequency-dependent increase in low threshold K+ current. J. Neuroscience 25(2): 363-371. PDF * Shared first author.  Faculty of 1000 citation.

McKay, B.E., Mehaffey, H.W., Molineux, M.L., and Turner, R.W. (2005) Kv1 K+ channels regulate Purkinje cell excitability to faciliate rebound depolarizations in deep nuclear neurons. J. Neuroscience 25(6): 1481-1492. PDF

McKay, B.E. and Turner, R.W. (2005) Physiological and morphological development of the rat cerebellar Purkinje cell. J. Physiology (Lond.) 567(Pt 3): 829-850. PDF

Fernandez, F.R., Mehaffey, W.H. and Turner, R.W. (2005) Dendritic Na+ current inactivation can increase cell excitability by delaying a somatic depolarizing afterpotential. J. Neurophysiology 94: 3836-3848. PDF

Mehaffey, W.H., Doiron, B., Maler, L. and Turner, R.W. (2005) Deterministic multiplicative gain control with active dendrites. J. Neuroscience 25(43): 9968-9977. PDF

Molineux, M.L.*, Fernandez, F.R.*, Mehaffey, W.H. and Turner, R.W. (2005) A-type and T-type currents interact to produce a novel spike latency-voltage relationship in cerebellar stellate cells. J. Neuroscience 25(47): 10863-10873. * Shared first author. PDF

Deng, W., Rashid, A.J., Fernandez, F.R., Maler, L., Turner, R.W. and Dunn, R.J. (2005) A C-terminal signal directs Kv3.3 channels to dendrites. J. Neuroscience 25(50): 11531-11541. PDF

Li X-F, Kiedrowski L, Tremblay F, Fernandez FR, Perizzolo M, Winkfein RJ, Turner, RW, Bains JS, Rancourt DE, and Lytton J. (2006) Importance of K+-dependent Na+/Ca2+-exchanger 2, NCKX2, in motor learning and memory. J. Biological Chemistry 281(10): 6273-6282. PDF

Molineux, M.L., McRory, J.E., McKay, B.E., Hamid, J., Mehaffey, W.H., Rehak, R., Snutch, T.P., Zamponi, G.W. and Turner, R.W. (2006) Specific T-type calcium channel isoforms are associated with distinct burst phenotypes in deep cerebellar nuclear neurons. PNAS 103(14): 5555-5560. PDF Supplementary data

Iftinca, M., McKay, B.E., Snutch, T.P., McRory, J.E., Turner, R.W. and Zamponi, G.W. (2006) Temperature dependence of T-type calcium channel gating. Neuroscience 142(4): 1031-1042. PDF

McKay, B.E., McRory, J.E., Molineux, M.L., Hamid, J., Snutch, T.P., Zamponi, G.W. and Turner, R.W. (2006) Cav3 T-type calcium channel isoforms differentially distribute to somatic and dendritic compartments in rat central neurons. European J. Neuroscience 24: 2581-2594. PDF

McKay, B.E., Engbers, J.D.T., Mehaffey, W.H., Gordon, G., Molineux, M.L., Bains, J. and Turner, R.W. (2007) Climbing fiber discharge regulates cerebellar functions by controlling the intrinsic characteristics of Purkinje cell output. J. Neurophysiology 97: 2590-2604. PDF

Fernandez, F.R., Engbers, J.D.T. and Turner, R.W. (2007) Firing dynamics of cerebellar Purkinje cells. J. Neurophysiology 98(1): 278-94. PDF    Faculty of 1000 citation.

Iftinca, M., Hamid, J., Chen, L., Varela, D., Tadayonnejad, R., Altier, C., Turner, R.W. and Zamponi, G.W. (2007) Regulation of T-type calcium channels by Rho-associated kinase. Nature Neuroscience 10 (7): 854-860. PDF

Mehaffey, W.H., Fernandez, F.R., Maler, L. and Turner, R.W. (2007) Regulation of burst dynamics improves differential encoding of stimulus frequency by spike train segregation. J. Neurophysiology 98(2): 939-951. PDF

Ellis, L.*, Mehaffey WH*, Harvey-Girard, E., Turner, R.W., Maler, L. and Dunn, R.J. (2007) SK channels provide a novel mechanism for the control of frequency tuning in electrosensory neurons. J. Neuroscience 27 (35): 9491-9502. *Shared first author. PDF

Mehaffey, W.H., Maler, L. and Turner, R.W. (2008) Intrinsic frequency tuning in ELL pyramidal cells varies across electrosensory maps. J. Neurophysiology 99(5): 2641-2655. PDF

Molineux, M.L., Mehaffey, W.H., Tadayonnejad, R., Anderson, D., Tennent, A.F. and Turner, R.W. (2008) Ionic factors governing rebound burst phenotype in rat deep cerebellar neurons. J. Neurophysiology 100: 2684-2701. PDF

Tadayonnejad, R., Mehaffey, W.H., Anderson, D. and Turner, R.W. (2009) Reliability of triggering postinhibitory rebound bursts in deep cerebellar neurons. Channels 3(3): 149-155. Open Access.

Anderson, D., Mehaffey, W.H., Iftinca, M., Rehak, R., Engbers, J.D.T., Hameed, S., Zamponi, G.W. and Turner, R.W.  (2010) Regulation of neuronal activity by Cav3-Kv4 channel signaling complexes. Nature Neuroscience 13: 333-337. Link   Faculty of 1000 citation.

Anderson, D., Rehak, R., Hameed, S., Mehaffey, W.H., Zamponi, G.W. and Turner, R.W. (2010) Regulation of the Kv4.2 complex by Cav3.1 channels. Channels 4(3): 163-167. Open Access PDF.

Engbers, J.D.T.*, Anderson, D.*, Tadayonnejad, R.*, Mehaffey, W.H., Molineux, M.L. and Turner, R.W. (2011) Distinct roles for IT and IH in controlling the frequency and timing of rebound spike responses. J. Physiol (Lond.), 589 (Pt 22): 5391-413. * Shared first authors. PDF

Engbers, J.D.T.*, Anderson, D.*, Asmara, H., Rehak, R., Mehaffey, W.H., Hameed, S., McKay, B.E., Kruskic, M., Zamponi, G.W. and Turner, R.W. (2012) Intermediate conductance calcium-activated potassium channels modulate summation of parallel fiber input in cerebellar Purkinje cells. PNAS, In Press.
* Shared first authors.

ii. Invited Reviews or Book Chapters: 

Turner R.W., Lemon, N., Doiron, B., Rashid, A.J., Morales, E., Maler, L., Longtin, and Dunn, R.J. (2002) Oscillatory burst discharge generated through conditional backpropagation of dendritic spikes. J. Physiol. (Paris) 96: 517-530. PDF

Mehaffey, W.H., Fernandez, F., Rashid, A.J., Dunn, R.J. and Turner, R.W. (2006) The distribution and function of potassium channels in aperonotid electrosensory lateral line lobe. J Comp Physiol A, Neuroethol Sens Neural Behav Physiol. 2006 20:1-12. Eprint

McKay, B.E. and Turner, R.W. (2006) Developing insights in Purkinje cell maturation. Physiology News, J. Physiol. (Lond.). PN1, No 63. PDF

McKay, B.E., Molineux, M.L., and Turner, R.W. (2007) Endogenous expression of biotin in central neurons. Methods in Molecular Biology, vol. 418: Avidin-Biotin Interactions. R. J. McMahon (ed) © Humana Press Inc., Totowa, NJ 418:111-128.

Mehaffey, W.H.*, Ellis, L.D.*, Krahe, R., Maler, L., Dunn, R.J. and Chacron, M.J. (2008) Ionic and neuromodulatory regulation of burst discharge. J. Physiol. (Paris) 102: 195-208. *Shared Authorship. PDF

Mehaffey, W.H., Fernandez, F.R., Doiron, B. and Turner, R.W. (2008) Regulation of somatic firing dynamics by backpropagating dendritic spikes. J. Physiol. (Paris) 102: 181-194. PDF

McKay BE, Tadayonnejad R, Anderson D, Engbers JDT., Fernandez FR,  and Turner, R.W.   Establishing in vivo like activity in rat cerebellar cells maintained in vitro. Isolated Neural Circuits, in Neuromethods (Ballanyi, K., ed.), Springer In Press.

Tadayonnejad, R., Anderson, D., Molineux, M.L., Mehaffey, W.H., Jayasuriya, K. and Turner, R.W. Rebound discharge in deep cerebellar nuclear neurons in vitro. Cerebellum 9(3): 352-374. PDF

Turner, R.W., Anderson, D. and Zamponi, G.W. (2011) Signaling complexes of voltage gated calcium channels. Channels 5(5): 440-448.

iii. Editor, Special Issue:

Turner, R.W., Maler, L., and Burrows, M. (eds) Electrolocation and electrocommunication. J. Experimental Biology 202(10), 1999.

IV. Abstracts – Published work since 2006

Hamid, J., Molineux, M.L., Snutch, T.P., Rehak, R., Turner, R.W., Zamponi, G.E. and McRory, J.E. Generation and characterization of novel and specific antibodies directed to the Cav3 family of calcium channels. Biophysics 2006.

Fernandez, F.R. and Turner, R.W. Dynamics of first spike latency with and without A-type currents: implications for cerebellar Purkinje cells. Comp Neurosci 2006.

Mehaffey, W.H., Fernandez, F.R., Maler, L. and Turner, R.W. Dendritic GABAb currents can induce a shift to a burst firing mode in ELL. Comp Neurosci. 2006.

Mehaffey, W.H., Fernandez, F.R. and Turner, R.W. Burst regulation modulates spike train segregration in the ELL of electric fish. Proc. Soc. Neurosci. 2006.

Fernandez, F.R. and Turner, R.W. Dynamical basis of bistability in cerebellar Purkinje cells.Proc. Soc. Neurosci. 2006.

Iftinca, M., Hamid, J., Turner, R.W., Zamponi, G.W. ROCK-mediated inhibition of T-type calcium channels. Biophys Soc. 2007.

Turner, R.W., Molineux, M.L., McRory, J.E., Snutch, T. and Zamponi, G.W. T type calcium channel function in deep cerebellar nuclei. Calcium Channel Conference, Moorea 2007.

McKay, B.E., Engbers, J.D.T., Mehaffey, W.H., Gordon, G.R.J., Molineux, M.L., Bains, J.S. and Turner, R.W. Climbing fibre control of Purkinje cell spike output. Can Assoc Neurosci 2007 [Can J. Neurol. Sci., 34 (Supplement 3): S87].

Molineux, M.L., Tennent, A.F., Mehaffey, W.H. and Turner, R.W. Ionic mechanisms of spike firing in two distinct types of rat deep cerebellar neurons. Proc. Soc. Neurosci. 2007.

Tadayonnejad, R., Molineux, M.L., Mehaffey, W.H. and Turner, R.W. Transient and Weak Bursting Deep Cerebellar neurons exhibit differential coding properties for membrane hyperpolarizations. Proc. Soc. Neurosci. 2007.

Mehaffey, W.H., Maler, L. and Turner, R.W. Distribution of intrinsic and bursting properties of basilar and non-basilar pyramidal cells across the maps of the electrosensory lateral line lobe. Proc. Soc. Neurosci. 2007.

Engbers, J.D.T., McKay, B.E. and Turner, R.W. Synaptic inputs regulate cerebellar Purkinje cell excitability by activating calcium-dependent potassium channels. Proc. Soc. Neurosci. 2007.

Hurlock, E.C., McMahon, A., McKay, B.E., Turner, R.W. and Joho, R.H. Purkinje cell-restricted restoration of Kv3.3 channel function rescues complex spikes and motor coordination in Kv3.3-mutant mice. Proc. Soc. Neurosci. 2007.

Mehaffey, W.H., Maler, L. and Turner, R.W. Feedback modulation of intrinsic firing dynamics restores feature detection in electrosensory processing. Comp. Neurosci. 2007.

Iftinca M, Anderson DM, Rehak R, Molineux ML, McRory J, Zamponi, GW. and Turner RW.   T-type calcium channels provide calcium-dependent modulation of A-type potassium channels. Can. Assoc. Neurosci. Montreal  2008.

Anderson, D.M., Mehaffey, W.H., Engbers, J.D.T, Rehak, R., Hamid, S., Zamponi, G.W. and Turner, R.W. T-type mediated calcium influx dynamically modulates Kv4 inactivation.  Can. Assoc. Neurosci. Vancouver  2009.

Anderson, D.M., Iftinca, M., Mehaffey, W.H., Rehak, R., Hami,d S., Zamponi, G.W. and Turner, R.W.  A-type potassium channels are dynamically regulated by T-type calcium current. IUPS  Kyoto 2009.

Anderson, D.M., Iftinca, M., Mehaffey, W.H., Rehak, R., Engbers, J.D.T., Hamid, S., Zamponi, G.W. and Turner, R.W.  Regulation of neuronal output by Cav3-Kv4 signalling complexes. Proc. Soc. Neurosci. 2009.

Tadayonnejad, R., Engbers, J.D.T., Anderson, D., Mehaffey, W.H. and Turner, R.W. The role of IH and IT in controlling rebound burst properties of Deep Cerebellar Nuclear cells. Can Assoc. Neurosci., 2010.

Tadayonnejad, R., Engbers, J.D.T., Anderson, D., Mehaffey, W.H. and Turner, R.W. IT and IH selectively regulate rate coding and spike precision in deep cerebellar nuclear cells. Proc. Soc. Neurosci., 2010.

Engbers, J.D.T., Anderson, D., Rehak, R., Mehaffey, W.H., McKay, B.E., Zamponi, G.W. and Turner, R.W.   T-type/IK channel signalling complex modulates summation of parallel fiber inputs in cerebellar Purkinje cells.  Can Assoc. Neurosci. 2010.

Engbers, J.D.T., Anderson, D., Rehak, R., Mehaffey, W.H., McKay, B.E., Zamponi, G.W. and Turner, R.W.   IKCa channels establish a high pass filter for parallel fiber input in cerebellar Purkinje cells.  Gordon Conference, Cerebellum in Health and Disease, New London, NH, 2011.

Engbers, J.D.T., Anderson, D., Rehak, R., Asmara, H., Mehaffey, W.H., Hameed, S., McKay, B.E., Kruskic, M., Zamponi, G.W., Turner, R.W.  IKCa-Cav3 complex reduces temporal summation of parallel fiber input in cerebellar Purkinje cells. IBRO World Congress of Neuroscience, Florence, Italy, 2011.

Engbers, J.D.T., Anderson, D., Rehak, R., Mehaffey, W.H., McKay, B.E., Kruskic, M., Zamponi, G.W., Turner, R.W.  IKCa-Cav3 complex creates a high pass filter for parallel fiber input in cerebellar Purkinje cells. Comp. Neurosci., Stockholm, Sweden, 2011. Prize, Student Poster Presentation.