Does the genome retain its integrity during development?
Today, we shall go to The University of Pittsburgh, where Dr. Richard Carthew will discuss genome equivalence and its consequences for development.
The text references in Dr. Carthew's module are to Gilbert (1997). Comparable material can be found in
Until recently, the evidence had been overwhelming that irreversible changes do occur in nuclei of adult animals that would preclude them from being reprogrammed to promote complete, normal development when implanted into an anucleate egg. However, Dolly has indicated that we may have been wrong. Mammalian cloning is now a reality. Use the mammalian cloning link to fulfil the following learning objectives:
Additional Learning Objectives for This Module
Chan, A.P. and Gurdon, J.B. 1996. Nuclear transplantation from stably transfected cultured cells of Xenopus. Int. J. Develop. Biol. 40: 441-451.
Browder, L.W., Erickson, C.A. and Jeffery, W.R. 1991. Developmental Biology. Third edition. Saunders College Pub. Philadelphia.
Gilbert, S.F. 1997. Developmental Biology. Fifth edition. Sinauer. Sunderland, MA.
Kalthoff, K. 1996. Analysis of Biological Development. McGraw-Hill. New York.
Shostak, S. 1991. Embryology. An Introduction to Developmental Biology. HarperCollins. New York.
Wolpert, L., Beddington, R., Brockes, J., Jessell, T., Lawrence, P. and Meyerowitz, E. 1998. Principles of Development. Current Biology. London.
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Leon Browder & Laurie Iten (Ed.) Dynamic Development
Last revised Thursday, June 25, 1998