SARS-CoV-2 Spike protein (S) gene S:p.H69_V70del;Y453F literature reference collection
Immunosuppression variant emergence
- The so-called "delta F" variant combination previously observed in mink spillover events also emerged in a lymphoma patient (non-Hodgkin diffuse B-cell lymphoma IV stage B) with a long-term COVID-19 infection (4 months) where 18 de novo mutation occureed overall.
Patient was taking rituximab, the B-cell-depleting agent, and had no detectable neutralizing antibody response. (Bazykin et al. (2021))
- Lentiviral pseudotyped with this mutation set from Mink Cluster 5 lineage, was tested on ACE2.293T cells. Luciferase activity was measured two days postinfection, showing slight decrease in infection rate amongst the cells, much closer to D614G activity level than Y453F alone, suggesting compensatory effects between the deletion and the mutation in human cell entry fitness.
(Tada et al. (2021))
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