Monoclonal antibody serial passage escape
- Moderately effective mutant against this position in the RBD for moderately neutralizing COV2-2082 monoclonal antibody.
Mildly effective mutant against this position in the RBD for moderately neutralizing COV2-2094 monoclonal antibody (Greaney et al. (2020))
- Escape mutation against monoclonal antibody LY-CoV016, with modest loss of ACE2 binding affinity.
(Starr et al. (2021))
- In vitro selection against class 1 (Spike 'up' conformation) monoclonal antibodies C614, C660, C664, C683, and to a lesser extent C678.
In vitro selection against class 2 (Spike 'up' or 'down' conformation, RBD targeting) monoclonal antibody C653. (Wang et al. (2021))
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