Antibody epitope effects
- This double substitution reduces neutralization by RBD-specific mAbs from different clusters, specifically, the cluster I mAb COVA2-29, cluster III mAb COVA2-07 and cluster VI mAb COVA1-12.
For COVA1-12 all neutralization activity is abolished, while COVA2-07 activity is just below the level required to calculate an IC50 value.
(Rees-Spear et al. (2021))
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