Monoclonal antibody serial passage escape
- The engineered mutation cause 10-fold or more increase in the disassociation constant with C135 and C110 monoclonal antibodies vs. wild type Spike protein RBD domain AAs.
Strong positive selection (up to 53% of supernatant sequences) under two rounds of C135 monoclonal antibody passage, overall 70% switch away from R346 to S, K or M (Weisblum et al. (2020))
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