SARS-CoV-2 Spike protein (S) gene S:p.T470N;E471V;I472P literature reference collection
Antibody epitope effects
- This mutation prevents neutralization by COVA2-29 (cluster I), COVA2-07 (cluster III) and COVA2-02 (cluster VII).
It also reduces the activity of the most potent mAb COVA1-18 (cluster I) by 3-fold, whereas this mAb is only minimally affected by other mutations. Moreover, TEI470-2NVP lowers the potency of the structurally unmapped non-RBD cluster XI mAb, COVA1-21, to the limit of detection.
Thus, this mutation negatively impacts the most mAbs, including representatives from four separate epitope clusters.
(Rees-Spear et al. (2021))
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