Antibody epitope effects
- Not in a major wildtype epitope, mutant increases PIWAS epitope score from 0.69% to 2.3%.
Found in B.1.1.7 lineage, but assumed to not pay a major role in antigenicity. (Haynes et al. (2021))
- Lentiviral pseudotyped with this individual mutation from B.1.1.7 was tested on ACE2.293T cells. Luciferase activity was measured two days postinfection, showing major decrease in infection rate amongst the cells, hence this individual variant is unlikely to contribute to cell entry fitness. T716I was expressed at significantly lower level, accounting for the decreased infectivity of this spike protein.
This property may be specific to spike protein biosynthesis in 293T cells and is not likely to reflect the situation in vivo given the reported increase in infectivity of the B.1.1.7 virus.
(Tada et al. (2021))
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