Antibody epitope effects
- Resistent to some neutralizing antibodies: mAbs X593 and P2B-2F6 (Li et al. (2020))
- Ablates binding by class 3 mAbs such as C135 that do not directly interfere with ACE2 binding, but clonal somatic mutations of memory B cells at 6.2 months (evolving humoral immune response) show pronounced increase in binding to the variant.
(Gaebler et al. (2021))
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