Immunosuppression variant emergence
- Based on structural modelling, this change detected on day 128 sequencing in a chronically infected patient would alter an extensive network of polar interactions with antibody residue R94VH, a germline antibody residue that is conserved in all of the potent VH3-53/3-66-derived antibodies isolated from a convalescent donor 5 weeks after infection.
(Clark et al. (2021))
Monoclonal antibody serial passage escape
- Escapes mAb REGN10933 (part of Regeneron's antibody cocktail) (Starr et al. (2020))
- Escape mutation against monoclonal antibody LY-CoV016, minimal ACE2 binding affinity loss (Starr et al. (2021))
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