SARS-CoV-2 mutation functional literature references

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SARS-CoV-2 genome schematic NSP1 - Host mRNA translation inhibiting [40S subunit binding] protein NSP1 - Host mRNA translation inhibiting [40S subunit binding] protein Spike Spike NSP2 - Prohibitin-interacting non-structural protein NSP2 - Prohibitin-interacting non-structural protein Papain-like protease / ER lumenal double-membrane vesicle forming complex member (a.k.a. NSP3) Papain-like protease / ER lumenal double-membrane vesicle forming complex member (a.k.a. NSP3) NSP4 - ER lumenal double-membrane vesicle forming complex member 3CL - 3C-like protease (a.k.a. NSP5, Mpro, main protease) 3CL - 3C-like protease (a.k.a. NSP5, Mpro, main protease) ER lumenal double-membrane vesicle forming complex member / IFN-I signalling suppressor NSP7 - Hexadecameric supercomplex member of the core replicase complex NSP8 - Adenylyltransferase / hexadecameric supercomplex member of the core replicase complex NSP9 - ssRNA-binding and orienting member of the replicase complex NSP10 - 2'-O-ribose type 1 cap methyltransferase cofactor NSP11 - Intrinsically disordered protein RdRp - RNA-dependent RNA polymerase member protein of the core replicase complex (a.k.a. NSP12) Hel - Helicase / packaging signal RdRp - RNA-dependent RNA polymerase member protein of the core replicase complex (a.k.a. NSP12) Hel - Helicase / packaging signal Contact Us ExoN - Exonuclease / guanine N7 methyltransferase / packaging signal (a.k.a. NSP14) ExoN - Exonuclease / guanine N7 methyltransferase / packaging signal (a.k.a. NSP14) EndoU - 5' subgenomic antisense transcript uracil endonuclease (a.k.a. NSP15) NSP16 - 2'-O-ribose type 1 cap methyltransferase ORF3a - Golgi-associating, caveolin-binding protein E - Envelope protein E - Envelope protein M - Matrix protein M - Matrix protein ORF6 - Nuclear import / interferon response inhibiting protein ORF7a - Cell cycle / program interferring protein ORF7b - Non-essential transmembrane protein ORF8 - Ig-like folding / IFN-I response interferring protein N - Nucleocapsid protein N - Nucleocapsid protein
Functional literature for Variants of Concern*/Interest/Under Monitoring lineages
A.27A.28+E484KA.VOI.V2AT.1AY.3AY.4.2B.1.1.318B.1.1.519B.1.1.529 (Omicron*)B.1.1.7 (Alpha*)B.1.1.7+E484KB.1.351 (Beta*)B.1.427 (Epsilon)B.1.429 (Epsilon)B.1.525 (Eta)B.1.526 (Iota)B.1.526.1B.1.616B.1.617B.1.617.1 (Kappa)B.1.617.2 (Deltai*)B.1.617.3B.1.620B.1.621 (Mu)B.1.640C.1.2C.16C.37 (Lambda)P.1 (Gamma*)P.2 (Zeta)P.3 (Theta)

Functional literature by gene

nsp1 — Host mRNA translation inhibiting [40S subunit binding] protein

nsp2 — Prohibitin-interacting non-structural protein

PLpro — Papain-like protease / ER lumenal double-membrane vesicle forming complex member (a.k.a. NSP3)

nsp4 — ER lumenal double-membrane vesicle forming complex member

3CL — 3C-like protease (a.k.a. NSP5, Mpro, main protease)

nsp6 — ER lumenal double-membrane vesicle forming complex member / IFN-I signalling suppressor

nsp7 — Hexadecameric supercomplex member of the core replicase complex

nsp8 — Adenylyltransferase / hexadecameric supercomplex member of the core replicase complex

nsp9 — ssRNA-binding and orienting member of the replicase complex

nsp10 — 2'-O-ribose type 1 cap methyltransferase cofactor

nsp11 — Intrinsically disordered protein

RdRp — RNA-dependent RNA polymerase member protein of the core replicase complex (a.k.a. NSP12)

Hel — Helicase / packaging signal

ExoN — Exonuclease / guanine N7 methyltransferase / packaging signal (a.k.a. NSP14)

EndoU — 5' subgenomic antisense transcript uracil endonuclease (a.k.a. NSP15)

nsp16 — 2'-O-ribose type 1 cap methyltransferase

S — Spike protein

ORF3a — Golgi-associating, caveolin-binding protein

E — Envelope protein

M — Membrane protein

ORF6 — Nuclear import / interferon response inhibiting protein

ORF7a — Cell cycle / program interferring protein

ORF7b — Non-essential transmembrane protein

ORF8 — Ig-like folding / IFN-I response interferring protein

N — Nucleocapsid

Functional literature by evidence type

ACE2 host variant dependency

ACE2 receptor binding affinity

CD8 plus T cell response

IFN activity

RNA binding

T cell evasion

Aerosolization

Anthropozoonotic events

Antibody epitope effects

Antigenic test failure

Caveolin binding

Clinical indicators

Convalescent plasma binding

Convalescent plasma escape

Dimerization

Environmental condition stability

Gene expression increase

Homoplasy

Humoral response durability

Immunosuppression variant emergence

Monoclonal antibody serial passage escape

Neutralizing plaque serial passage escape

Outcome hazard ratio

Pharmaceutical effectiveness

Posttranslational modifications

Protein cleavage

Reinfection

Remdesivir failure

Stress granule inhibition

Subgenomic RNA expression

Symptom prevalence

Syncytium formation

Tissue specific neutralization

Tissue specific replication effects

Trafficking

Transmissibility

Vaccine efficacy

Vaccine neutralization efficacy

Vaccine specific variants

Vaccinee plasma binding

Variant linear antibody epitope effects

Viral load

Virion structure