- Deletions in the genomic nucleotide 500-523 range are shown in vitro culture to downregulated interferon A1/2 & B1 expression, and are associated with lower clinical severity of disease (Jan-Mar 2020 in China).
variations of deletion in this region are found in separate lineages throughout the globe.
This specific deletion (genomic 518-523) was tested in vitro for IFN response. (Lin et al. (2021))
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