Dr. Kenneth K.-S. Ng

Department of Biological Sciences
University of Calgary
2500 University Drive, N.W.
Calgary, Alberta, Canada
T2N 1N4

Phone: (403) 220-4320
Fax: (403) 289-9311
E-mail: ngk@ucalgary.ca


  • Publications indexed by Pubmed
  • Google Scholar

  • Our primary research interest is in understanding how biological macromolecules function at the molecular level.

    Our lab is particularly interested in understanding how the three-dimensional structures of proteins have evolved to act as highly specific and efficient chemical catalysts (enzymes) or binding proteins.

    The main techniques that we use for our studies are molecular biology, protein expression and purification, and X-ray crystallography. We also use other biochemical, biophysical and computational techniques to explore how enzymes and binding proteins function.

    Research Interests

    Our lab focuses on a few different systems:

  • RNA-dependent RNA Polymerases
    • RNA-dependent RNA polymerases are the central enzymes responsible for replicating the genomes of positive-strand RNA viruses. Positive-strand RNA viruses are the cause of many human diseases -- such as polio, the common cold, hepatitis A, hepatitis C, dengue fever, viral encephalitis (West Nile virus), viral gastroenteritis (noroviruses) and Severe Acute Respiratory Syndrome (SARS). Positive-strand RNA viruses also cause many serious diseases in other animals (for example, foot-and-mouth disease, rabbit hemorrhagic disease, feline calicivirus disease, porcine respiratory and reproductive syndrome, and equine viral arteritis) and plants (for example, plum pox and barley yellow disease).

    • Caliciviruses
  • Carbohydrate-binding proteins

  • Meetings and Conferences

  • Canadian Glycomics Symposium 2018 -- Banff, Alberta, May 9-11
  • American Crystallographic Association 2018 -- Toronto, Ontario, July 20-24
  • Plant Biology 2018 -- Montreal, Quebec, July 14-18

  • Local access to references and journals

  • University of Calgary Library
  • UofC Ebooks
  • UofC SpringerLink Books
  • UofC Ebrary
  • UofC Health Sciences Ebooks
  • ProQuest Dissertation Repository
  • Dictionaries and Encyclopedias

  • Oxford English Dictionary Online
  • Oxford Reference Online
  • Encyclopedia of Life Sciences
  • Journal Indexes

  • Faculty of 1000
  • Web of Knowledge
  • Web of Science
  • InCites Journal Citation Reports
  • SpringerLink
  • ScienceDirect
  • Wiley Journals
  • Scopus
  • General

  • Cell
  • Nature
  • PNAS
  • Science
  • JoVE Journal of Visualized Experiments
  • Structure and Crystallography

  • Cambridge Crystallographic Data Centre -- structure download
  • Acta Crystallographica Sect. D
  • Structure
  • Space Group Diagrams -- Dept. Chem., Birkbeck College, UCL
  • Chemistry

  • Royal Society of Chemistry
  • Journal of Medicinal Chemistry
  • Biochemistry

  • Analytical Biochemistry
  • Archives of Biochemistry and Biophysics
  • Biochemical and Biophysical Research Communications
  • Biochemistry (ACS)
  • Biochemistry and Molecular Biology Education
  • Journal of Biological Chemistry
  • Journal of Molecular Biology
  • Methods in Enzymology
  • Annual Reviews of Biochemistry
  • Virology

  • Journal of General Virology
  • Journal of Virology
  • Virology

  • Research links

  • AGC -- Alberta Glycomics Centre
  • GlycoNet -- Canadian Glycomics Network
  • CFG -- Consortium for Functional Glycomics
  • CERMAV -- CNRS, Grenoble
  • GlycoSciences.DE -- SWEET2 and other useful tools and databases from Germany
  • GlyTorsion -- conformations of glycosidic linkages
  • Linker Database -- Centre for Integrative Bioinformatics from Vrije Universiteit, Amsterdam
  • Catalytic Site Atlas -- Janet Thornton, EBI
  • Enzyme Structure Database -- Janet Thornton, EBI, PDBSum
  • PyIgClassify -- Roland Dunbrack, FCCC, Clusters of Antibody CDRs

  • Local links

  • University of Calgary
  • Department of Biological Sciences
  • Departmental Home Page for Dr. Ng
  • Protein Crystallography Facility at the University of Calgary

  • Teaching links

  • Info for Biochemistry Majors -- at the University of Calgary
  • Biochemistry Teaching (Dr. Isabelle Barrette-Ng) -- Some very interesting interactive tutorials & quizzes
  • University of Rochester -- Crystallography & Enzymology -- ( Dr. Joseph E. Wedekind) -- Some very nice content
  • BCEM 431 -- Proteins and Proteomics
  • BCEM 543 -- Enzymology
  • MDSC 755 -- Mass Spectrometry and Crystallography
  • BCEM 731 -- Protein & Metabolic Engineering
  • Crystallography -- Learning resources Biology

  • Useful Sites

  • NIST Time Server -- Mountain time zone

  • News!

  • Congratulations to Miguel Torres (Ph.D. Candidate) for winning the PDB Poster Award at the 66th Annual Meeting of the American Crystallographic Association (July 22-26, 2016) and the PDB Poster Award at the 67th Annual Meeting of the ACA (May 26-30, 2017). Go for the three-peat in Toronto, Miguel!

  • This page was last updated on January 6, 2018. Thanks for visiting!