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Steven Dykstra

Steven Dykstra,  BEng Univ. Alberta
MSc Student,
Dept. Neuroscience, 2015
Hotchkiss Brain Institute
Health Research Innovation Center (HRIC) 1B42A
University of Calgary
Calgary Alberta Canada
T2N 4N1
Phone: 403-220-8451
FAX: 403-210-7446
sdykstra@ualberta.ca

Training
BEng 2012
University of Alberta
Alberta Canada

MSc 2012-2015
Department of Neuroscience
University of Calgary


Awards
BEng
NSERC Undergraduate Student Research Award, 2012
Louise McKinney Post-Secondary Scholarship
Jason Lang Scholarship, 2010

MSc
Queen Elizabeth II Award, Dept. Neuroscience
Research Focus: Signal processing in deep cerebellar neurons
Approach: I use patch clamp recordings in vitro to determine the ability for deep cerebellar neurons to respond to the inhibitory input of Purkinje cells
Preparations: In vitro slice preparation, optogenetics, dynamic clamp
Below are short summaries of my projects published from the lab.
Biocytin-filled DCN neuron and MAP-2 labeled dendritic processes

Model - Deep nuclear neurons
    Deep nuclear neurons represent the final output of cerebellum after integrating afferent excitatory pontine inputs and inhibitory input from cerebellar cortical Purkinje cells. These cells spontaneously discharge at rest but can respond to Purkinje cell inhibition with a transient rebound burst discharge. My project involves the use of patch clamp recordings and stimulation of synaptic inputs to understand the regulation and functional role of burst output in response to physiological patterns of input.

IKCa channels are a major determinant of the CA1 hippocampal pyramidal cell sAHP IKCa channels are a critical determinant of the CA1 pyramidal cell slow AHP
   CA1 pyramidal cells have been shown to express immunolabel and promoter activity of the IKCa channel. Recordings of the slow AHP in CA1 pyramidal cells revealed single channels that match the pharmacological profile of IKCa channels, which prove to underlie the long duration slow AHP. Block of IKCa channels confirm a key role in reducing temporal summation of EPSPs and mediating spike accommodation. (see King et al. (2015)).

Peer-reviewed Publications

King, B.*, Rizwan, A.P.*, Asmara, H., Heath, N.C., Engbers, J.D.T, Dykstra, S., Bartoletti, T.M., Hameed, S., Zamponi, G.W., and Turner, R.W. (2015) IKCa channels are a critical determinant of the slow AHP in CA1 pyramidal neurons. * Shared first authors. Cell Reports. 11:1-8. Link

Dykstra, S., Engbers, J.D. T., Bartoletti, T.M. and Turner, R.W.  (2015) Determinants of rebound burst responses in rat cerebellar nuclear neurons to physiological stimuli. J. Physiology (Lond). 594(4): 985-1003.

Invited Reviews or Book Chapters

Dykstra, S. and Turner, R.W. Rebound depolarizations and potentiation. In: Essentials of Cerebellum and Cerebellar Disorders. Chapter 6.4, D. Gruol (ed.), Springer, NY. In Press.


Abstracts

Dykstra, S., Engbers, J.D.T., Bartoletti, T.M., Bosman, L.W.J, Owens, C.B., deZeeuw, C.I., and Turner, R.W. Deep cerebellar neurons differentially encode inhibitory inputs of Purkinje cells. Can. Assoc. Neurosci., 2013.

Dykstra, S., Engbers, J.D.T., Bartoletti, T.M., Bosman, L.W.J, Owens, C.B., deZeeuw, C.I., and Turner, R.W.  Deep cerebellar neurons differentially encode inhibitory inputs of Purkinje cells. Cerebellar Gordon Conference, 2013.

King, B., Rizwan, A. P., Heath, N.C., Asmara, H., Dykstra, S., Zamponi, G.W. and Turner, R.W. Novel roles for IKCa channels in rodent hippocampal CA1 pyramidal neurons. Proc. Soc. Neurosci., 2014.

King, B.*, Rizwan, A.P.*, Heath, N.C., Asmara, H., Dykstra, S., Zamponi, G.W. and Turner, R.W.  IKCa channels are a critical determinant of the slow AHP in hippocampus.  Can. Assoc. Neurosci., 2015.

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