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Brian King

Brian King
BSc Biochem Biomed, McMaster Univ., 2012
MSc Neuroscience, 2014

Hotchkiss Brain Institute
Health Research Innovation Center (HRIC) 1B42A
University of Calgary
Calgary Alberta Canada
T2N 4N1
Phone: 403-220-8451
FAX: 403-210-7446
kingbd2@gmail.com

Training
BSc 2012
McMaster University
Ontario Canada

MSc 2012 - 2014
Department of Neuroscience
University of Calgary

Awards
BSc
Golden Key International Honour Society member
McMaster Entrance Honour Award
Queen EII Scholarship 2008-11


MSc
Queen Elizabeth II Award, Dept. Neuroscience
TAship, Cellular and Molecular Neuroscience
FGS Travel Award
Brain Star Award, CIHR Inst Neuroscience

Research Focus: The functional role of KCa3.1 potassium channels in CNS neurons
Approach: I use patch clamp recordings in vitro to examine how the calcium-dependent potassium channel KCa3.1 controls neuronal excitability
Preparations: In vitro slice preparation, optogenetics, voltage clamp
Below are short summaries of my projects published from the lab.
IKCa channels are a major determinant of the CA1 hippocampal pyramidal cell sAHP IKCa channels are a critical determinant of the CA1 pyramidal cell slow AHP
   CA1 pyramidal cells have been shown to express immunolabel and promoter activity of the IKCa channel. Recordings of the slow AHP in CA1 pyramidal cells revealed single channels that match the pharmacological profile of IKCa channels, which prove to underlie the long duration slow AHP. Block of IKCa channels confirm a key role in reducing temporal summation of EPSPs and mediating spike accommodation. (see King et al. (2015)).

Peer-reviewed Publications

King, B.*, Rizwan, A.P.*, Asmara, H., Heath, N.C., Engbers, J.D.T., Dykstra, S., Bartoletti, T.M., Hameed, S., Zamponi, G.W. and Turner, R.W.  (2015) IKCa channels are a critical determinant of the slow AHP in CA1 pyramidal neurons.  Cell Reports 11: 1-8. *Shared first authors. Link


Abstracts

King, B., Teves, M., Seredynski, T., Kruskic, M., Asmara, H., Engbers, J.D.T., Hameed, S., Zamponi, G.W. and Turner, R.W. Expression pattern of the intermediate conductance Ca-activated K channel in the CNS. Can. Assoc. Neurosci., 2013.

King, B., Teves, M., Kruskic, M., Asmara, H., Engbers, J.D.T., Hameed, S., Zamponi, G.W. and Turner, R.W. Widespread expression of the intermediate conductance Ca-activated K channel in central neurons. Cerebellar Gordon Conference, 2013.

King, B.*, Rizwan, A.P.*, Heath, N.C., Asmara, H., Dykstra, S., Zamponi, G.W. and Turner, R.W. Novel roles for IKCa channels in rodent hippocampal CA1 pyramidal neurons. Proc. Soc. Neurosci., 2014.

King, B.*, Rizwan, A.P.*, Heath, N.C., Asmara, H., Dykstra, S., Zamponi, G.W. and Turner, R.W.  IKCa channels are a critical determinant of the slow AHP in hippocampus.  Can. Assoc. Neurosci., 2015.

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