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X Zhan
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Jason Miclat

Jason de Mesa Miclat
BEng 2005 McMaster University ON
BSc
2014 Ryerson University ON
MSc Student, Dept. Neuroscience, In Progress 2015-

Hotchkiss Brain Institute
Health Research Innovation Center (HRIC) 1B42A
University of Calgary
Calgary Alberta Canada
T2N 4N1
Phone: 403-220-8451
FAX: 403-210-7446
jason.miclat@gmail.com     jason.miclat@ucalgary.ca

Training
BSc 2012
McMaster University
Ontario Canada

MSc 2015 -
Department of Neuroscience
University of Calgary

Awards
BSc
Hospital Auxiliary Assoc. Ontario Service Award
Heather Funston Memorial Scholarship
Milton Hospital Life Time Member Award

MSc
Hotchkiss Brain Institute MSc Studentship
Cumming School of Medicine Studentship


Research Focus: The functional role of KCa3.1 potassium channels in CNS neurons
Approach: I use patch clamp recordings in vitro to examine how the calcium-dependent potassium channel KCa3.1 is controlled by calcium sensing mechanisms in CA1 hippocampal pyramidal cells
Preparations: In vitro slice preparation, tsA cells, protein biochemistry, voltage clamp
Below are short summaries of my projects published from the lab.
IKCa channels are a major determinant of the CA1 hippocampal pyramidal cell sAHP

Mechanisms for activating IKCa channels and the sAHP of CA1 pyramidal cells
   CA1 hippocampal pyramidal cells exhibit a slow AHP of seconds duration that involves the activation of an intermediate conductance calcium-gated potassium channel (IKCa, KCa3.1) (King et al., 2015). My work uses patch clamp electrophysiology of cDNA constructs transiently expressed in tsA-201 cells and in CA1 pyramidal cells together with protein biochemistry to examine the underlying basis for activation of the sAHP.

Peer-reviewed Publications

Turner, R.W., Asmara, H., Engbers, J.D.T., Miclat, J., Rizwan, A.P., Sahu, G., and Zamponi, G.W. (2016) Assessing the role of IKCa channels in generating the slow AHP of CA1 hippocampal pyramidal cells. Channels 10(4): 313-319. Link


Key Abstracts / Presentations

Sahu, G., Miclat J., Zamponi G.W., Turner, R.W.  L-type voltage gated calcium channels activate
IKCa channels to generate the slow afterhyperpolarization in CA1 pyramidal cells. Research Day, Hotchkiss Brain Inst., 2015.


Sahu, G., Miclat J., Zamponi G.W., Turner, R.W.  L-type voltage gated calcium channels activate
IKCa channels to generate the slow afterhyperpolarization in CA1 pyramidal cells. Proc. Soc. Neuroscience, Chicago, 2015.

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